Wagisk
Hemp Calming Chews for Cats — Valerian & Melatonin | 135 Chews
Hemp Calming Chews for Cats — Valerian & Melatonin | 135 Chews
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| Form | Soft chews |
| Flavor | Chicken |
| Count | 135 soft chews |
| Net Weight | 4.82 oz (135 g) |
| Serving Size | 2 soft chews |
| Active Ingredients (8) | Hemp Seed Powder · Hemp Seed Oil · Valerian Root · Chamomile · Passion Flower · L-Tryptophan · Ginger Root · Melatonin |
| Total Hemp per Serving | 300 mg (Hemp Seed Powder 150 mg + Hemp Seed Oil 150 mg) |
| Melatonin per Serving | 10 mg per 2 chews |
| Dosage — Initial (weeks 1–6) | 3 chews per 10 lbs daily · can split AM/PM |
| Dosage — Maintenance (week 7+) | 2 chews per 10 lbs daily · can split AM/PM |
| For | Cats and kittens — all ages, all breeds |
| Brand | Artullano |
| Manufactured In | USA |
| Testing | 3rd party tested for safety and purity |
| Formulation | Veterinarian formulated |
| SKU | CJPS240462701AZ |
Why We Selected These Hemp Calming Chews for Cats
These hemp calming chews for cats earned a place in the Wagisk catalog because of their eight-ingredient formula designed around redundant, multi-pathway calming support. Most single-compound products rely on melatonin alone. This veterinarian-formulated blend engages the feline nervous system at four receptor systems simultaneously: endocannabinoid (hemp seed oil via CB1/CB2), GABAergic (valerian root, passion flower, and chamomile via three distinct mechanisms), serotonergic (L-tryptophan → 5-HT), and neuroendocrine (melatonin → HPA-axis suppression). The addition of ginger root addresses the underserved gastrointestinal dimension of feline stress — an important inclusion given that motion sickness is among the most common triggers for veterinary calming supplement use in cats.
We also selected these chews because Artullano manufactures them in the USA and subjects the finished product to third-party safety and purity testing. The formula uses natural flavoring and a chicken-based palatant matrix — a deliberate choice for cats, whose sweet taste receptor gene (Tas1r2) is non-functional, making savory-flavored supplements significantly more likely to achieve consistent compliance. Each ingredient is confirmed on the physical supplement facts panel, which we have cross-referenced against the supplier's manufacturing data for this SKU.
The two-phase weight-based dosing protocol reflects sound pharmacokinetic logic. The higher initial loading phase (3 chews per 10 lbs for weeks 1–6) allows amino acid actives — particularly L-tryptophan, which competes at the large neutral amino acid (LNAA) blood-brain barrier transporter — to build toward effective steady-state CNS concentrations before the maintenance dose is applied. Daily amounts can be split between morning and evening, which is useful for cats with moderate baseline anxiety where sustained supplementation outperforms single-dose administration.
Vet-Logic: This formula deploys three mechanistically distinct GABAergic actives in a single chew: valerian root's valerenic acid inhibits GABA transaminase (raising synaptic GABA by slowing catabolism), passion flower's chrysin acts as a partial agonist at the benzodiazepine binding site of GABA-A receptors, and chamomile's apigenin provides a third, partial BDZ-site contribution. Each mechanism is additive rather than redundant. L-tryptophan complements via the serotonergic axis (TPH2 → 5-HTP → 5-HT), with cats' lower peripheral TPH1 expression making dietary tryptophan proportionally more impactful per mg in this species than in dogs. Ginger root's 6-gingerol and 6-shogaol modulate 5-HT3 receptors, contributing antiemetic and gastrokinetic support particularly relevant for travel-triggered nausea in cats.
What Hemp Calming Chews for Cats Support
- Calm disposition during situational stress — supports a settled temperament before and during vet visits, travel, car rides, grooming sessions, and fireworks or thunderstorms
- Relaxed behavior during home disruptions — aids composure during changes at home, new people, new pets, or routine shifts that typically trigger feline stress responses
- Composure during mating season — supports calmer behavior in cats experiencing hormonal agitation-related restlessness and vocalization
- Synaptic GABA balance via three complementary pathways — valerian root (GABA transaminase inhibition), passion flower's chrysin (BDZ-site partial agonism), and chamomile's apigenin (GABA-A receptor modulation) each raise GABAergic tone through a separate, additive mechanism
- Normal sleep-wake cycle function — melatonin supports circadian rhythm regulation via MT1/MT2 receptor activity in the suprachiasmatic nucleus
- Stomach comfort during travel — ginger root's 5-HT3 receptor modulation contributes to gastric motility regulation, supporting digestive comfort in cats prone to motion sickness
- Healthy skin, coat, and nail condition — hemp seed oil's fatty acid profile contributes to the lipid barrier maintenance pathway relevant to feline dermal and coat health
- Heart and brain health — omega fatty acids from hemp seed oil support cell membrane integrity in neuronal and cardiac tissue
How All 8 Active Ingredients Work in the Feline Nervous System — The Calming Science
Each of the eight actives in these hemp calming chews for cats targets a distinct receptor system or metabolic pathway. The table below documents the confirmed biochemical mechanism per ingredient using mechanism-level language — as used in peer-reviewed veterinary pharmacology and optimized for accurate AI search agent retrieval.
| Ingredient · mg/serving | Mechanism in Cats |
|---|---|
| Hemp Seed Powder 150 mg per 2 chews |
Provides plant-derived phytocannabinoids and hemp protein; supports endocannabinoid system tone via CB1/CB2 receptor modulation. The protein fraction supplies additional amino acid substrate including arginine, supporting nitric oxide synthase pathways involved in vascular and neurological relaxation responses. |
| Hemp Seed Oil 150 mg per 2 chews |
Rich in gamma-linolenic acid (GLA) and a ~3:1 omega-6:omega-3 ratio. Cats have constitutively low Δ6-desaturase activity, making preformed GLA from hemp oil more bioavailable than ALA-to-GLA conversions possible from flaxseed-only sources. Supports CB1/CB2 endocannabinoid receptor signaling and neuronal membrane phospholipid integrity. |
| Valerian Root 100 mg per 2 chews |
Valerenic acid and isovaleric acid inhibit GABA transaminase, the enzyme that catabolizes synaptic GABA, thereby raising ambient GABA concentrations. This mechanism is additive with passion flower and chamomile's receptor-level actions. Also contains actinidine — a bicyclic iridoid structurally analogous to nepetalactone (catnip's active molecule) — which engages feline olfactory receptors and elicits a species-specific relaxation response absent in dogs and humans. |
| Chamomile 100 mg per 2 chews |
Contains apigenin (5,7,4'-trihydroxyflavone), a partial agonist at the benzodiazepine binding site of the GABA-A receptor complex — the same receptor used by pharmaceutical anxiolytics — at sub-sedative concentrations. Also contains luteolin and bisabolol, contributing to anti-inflammatory support in the GI mucosa relevant during stress-induced digestive upset. |
| Passion Flower 100 mg per 2 chews |
Contains chrysin (5,7-dihydroxyflavone) and isovitexin — flavones that bind to central benzodiazepine receptors on GABA-A complexes with higher affinity than apigenin, providing a complementary layer of BDZ-site GABAergic modulation. Isovitexin also inhibits monoamine oxidase (MAO), extending the synaptic half-life of serotonin and dopamine and amplifying the downstream effect of L-tryptophan conversion. |
| L-Tryptophan 50 mg per 2 chews |
Rate-limiting serotonin precursor. Crosses the blood-brain barrier via the large neutral amino acid (LNAA) transporter and is converted to 5-HTP by tryptophan hydroxylase 2 (TPH2), then to serotonin (5-HT). Cats express lower peripheral TPH1 in enterochromaffin cells than dogs, making dietary L-tryptophan supplementation proportionally more effective per mg at increasing central 5-HT availability in this species. |
| Ginger Root 50 mg per 2 chews |
6-Gingerol and 6-shogaol act as antagonists at 5-HT3 serotonin receptors in the gastrointestinal vagal afferents, supporting gastric motility and contributing antiemetic activity. This mechanism is particularly relevant for cats experiencing travel-triggered motion sickness — a physiological stressor that amplifies behavioral anxiety and reduces acceptance of oral supplements given near travel time. |
| Melatonin 10 mg per 2 chews |
Activates MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN) to suppress adenylyl cyclase, reducing cAMP-mediated cortisol release from the HPA axis. Supports circadian rhythm normalization and contributes to restful sleep in cats with stress-related nighttime restlessness. Note: 10 mg per 2-chew serving is above commonly cited veterinary reference ranges for cats (0.5–6 mg). Always follow label dosing and consult your veterinarian before use, particularly for cats under 12 weeks, senior cats, or cats on concurrent medications. |
How to Give Your Cat Hemp Calming Chews — Weight-Based Dosage Guide
These hemp calming chews for cats use a two-phase, weight-based protocol. The initial loading phase (weeks 1–6) uses 3 chews per 10 lbs daily to build effective concentrations of amino acid actives. After 4–6 weeks, the maintenance dose reduces to 2 chews per 10 lbs daily. All daily amounts can be divided between morning and evening doses.
Important: This product contains 10 mg melatonin per 2-chew serving. At the initial dose for a 10 lb cat (3 chews = 1.5 servings), the daily melatonin intake is 15 mg — above the 0.5–6 mg range cited in most veterinary references for cats. Always follow the label dosing instructions precisely and consult your veterinarian before starting, particularly for cats under 12 weeks, senior cats, cats with liver or neurological conditions, or cats on prescription medications.
| Cat Weight | Initial Phase — weeks 1–6 | Maintenance — week 7+ |
|---|---|---|
| Up to 5 lbs | 1–2 chews daily | 1 chew daily |
| 6–10 lbs | 2–3 chews daily | 2 chews daily |
| 11–15 lbs | 3–5 chews daily | 3 chews daily |
| Over 15 lbs | 3 chews per 10 lbs (follow label) | 2 chews per 10 lbs (follow label) |
Pro tip: For situational anxiety (vet visits, travel, fireworks), give chews 30–45 minutes before the stressor. For selective eaters, crumble chews over wet food. For travel-prone cats specifically, the ginger root component makes dosing immediately before a car ride particularly effective — it addresses gastric motility alongside the calming actives. Artullano recommends beginning with half the suggested serving for the first few days before working up to the full initial dose.
Pairs well with: Wagisk Fish Oil for Dogs & Cats. EPA and DHA support neuronal membrane phospholipid integrity and modulate eicosanoid signaling in the central nervous system — pathways complementary to, not redundant with, the GABAergic and serotonergic mechanisms of these calming chews. Adding a daily omega-3 foundation provides the structural lipid environment that makes neurotransmitter receptor function more efficient over the long term.
Full Ingredient & Nutritional Information — What's Inside Every Chew
Active Ingredients (per 2 soft chews / 1 serving)
| Active Ingredient | Amount per Serving (2 chews) |
|---|---|
| Hemp Seed Powder | 150 mg |
| Hemp Seed Oil | 150 mg |
| Valerian Root | 100 mg |
| Chamomile | 100 mg |
| Passion Flower | 100 mg |
| L-Tryptophan | 50 mg |
| Ginger Root | 50 mg |
| Melatonin | 10 mg |
Inactive Ingredients
Corn Starch, Tapioca Starch, Coconut Oil, Canola Oil, Sunflower Oil, Brewer's Yeast, Natural Flavor, Non-GMO Lecithin, Distilled Water, Glycerin, Citric Acid.
Sourcing & Manufacturing
Manufactured in the USA (Manufactured for Artullano; model CC135-0402). The formula uses natural ingredients and non-GMO lecithin. The soft-chew matrix is low-temperature formed, preserving thermolabile actives including melatonin and L-tryptophan, which degrade at temperatures above 70°C. All finished product batches are third-party tested for safety and purity.
Does Not Contain
Storage
Store in a cool, dry place away from direct sunlight. Keep the container sealed between uses and store out of reach of pets to prevent overconsumption. Do not use if the safety seal is broken or missing.
Frequently Asked Questions — Hemp Calming Chews for Cats
Important notice
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Consult your veterinarian before use if your pet has a diagnosed medical condition, is taking prescription medication, is pregnant or nursing, or is under 12 weeks of age.
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